A narrative review about the association between Sjögren’s syndrome and pregnancy

B.M. Danciu, A.M.A. Stănescu, M. Vieru, A.A. Simionescu

Rezumat: Sjögren syndrome (SS) is one of the most frequently autoimmune systemic diseases that may influence pregnancy outcome, and pregnancy may influence its evolution. SS increases the risk of fetal complications, including neonatal lupus and congenital heart diseases, and even causes loss of pregnancy. In this article, we provide a review of particularities of SS during pregnancy and the recommended management. The gestation period is contraindicated for most antirheumatic drugs, and there is an overexpression of symptoms and a higher risk of associated complications. Therefore, every woman should have an antenatal management to effectively control the basic pathology, and to be explained in detail the risks that can occur in case of a pregnancy both for her and for the conception product. If the pregnant woman’s state deteriorates or in case of fetal complications, there are a series of therapies that can be used which provide more or less effective solutions. In conclusion, Sjögren’s syndrome remains difficult to diagnose during pregnancy and challenging to manage when diagnosed.
Cuvinte cheie: Sjögren syndrome, pregnancy, antinuclear antibodies, SS-A antibodies (anti-Ro), SS-B antibodies (anti- LA), congenital neonatal lupus.